PHYTOFLORA IMMUNOLIX 500 MG
60 VEGGIE CAPSULES

This product joins the potency of two well known bee by products: Propolis and Royal Jelly.

The action of these two products has been tested over time by popular medicine.

Immunolix 500 mg is a supplement that gathers in each capsule 200 mg of pure Brazilian Green Bee Propolis Dry Extract concentrated at 50% with the equivalent of 900 mg of Uncontaminated Fresh Royal Jelly.

Immunolix 500 mg helps people to boost the immune system.

Royal Jelly has been found to be of great help in boosting the body's resistance to the harmful side effects of chemotherapy and radiotherapy.

These treatments attack the immune system at its very core, and in many cases the actual treatment delivers a debilitating blow and not the illness itself.

 Royal Jelly with its high amino acid content can help the immune system and provide a basic defense against external elements that ordinarily attack the immune system and reduce our body's capability for defense.

Supplementing our diet with Royal Jelly helps to rebuild the good cells that are destroyed by chemotherapy and helps to strengthen the immune system.

 Royal Jelly also contains the amino and gamma globulin, which helps your immune system fight off viral infections. It also contains sterols, phosphorous compounds and acetylcholine, which is needed to transmit nerve messages from cell to cell.

 

Some Studies of Propolis and Royal Jelly

Immune activation and radioprotection by propolis.

Takagi Y, Choi IS, Yamashita T, Nakamura T, Suzuki I, Hasegawa T, Oshima M, Gu YH.

Graduate School of Health Science, Suzuka University of Medical Science 1001-1 Kishioka-cho, Suzuka-shi, Mie 510-0293, Japan.

In this study, we focused on immune stimulation by Propolis, and examined changes in the effect of irradiation after Propolis administration. We also examined the radioprotective effect of Propolis by observing its effect on the immune system. The effect of immune activation by Propolis was investigated by measuring the total immunoglobulin (Ig) G and IgM. The radioprotective effect of immune activation by Propolis was investigated by measuring the T-lymphocyte subsets in the peripheral blood of mice following whole body irradiation. Compared with the control group, the IgG was significantly reduced in the Propolis group, indicating that Propolis suppressed IgG production. ELISA revealed that the amount of IgM in mouse serum was significantly higher in the Propolis group as compared with the control group, indicating that Propolis increased IgM production. The number of CD4-positive cells was increased only in the Propolis group. Likewise, the number of CD4-positive cells increased by 81% in the Propolis with irradiation group compared with the irradiation group alone. Compared with the control group, the Propolis group increased CD8-positive cells. Compared with the irradiation alone group, CD8-positive cells were decreased by Propolis with irradiation group. Propolis activated macrophages to stimulate interferon (IFN)-gamma production in association with the secondary activation of T-lymphocytes, resulting in a decrease in IgG and IgM production. Cytokines released from macrophages in mouse peripheral blood after Propolis administration activated helper T-cells to proliferate. In addition, activated macrophages in association with the secondary T-lymphocyte activation increased IFN-gamma production and stimulated proliferation of cytotoxic T-cells and suppressor T-cells, indicating the activation of cell-mediated immune responses.

PMID: 15974482 [PubMed - indexed for MEDLINE]

Major royal jelly protein 3 modulates immune responses in vitro and in vivo.

• Okamoto I,

• Taniguchi Y,

• Kunikata T,

• Kohno K,

• Iwaki K,

• Ikeda M,

• Kurimoto M.

Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc., 675-1 Fujisaki, 702-8006 Okayama, Japan. kohnok@hayashibara.co.jp

We have recently shown that royal jelly has potent antiallergic properties in a mouse model of immediate hypersensitivity. However, it is still unclear which components of royal jelly exhibit antiallergic activity. In this study, we have screened for antiallergic factors in royal jelly based on inhibition of IL-4 production by anti-CD3 stimulated spleen cells derived from OVA/alum-immunized mice. Using a series of column chromatographies, we purified a 70 kDa glycoprotein, major royal jelly protein 3 (MRJP3), that suppresses IL-4 production. In in vitro experiments, MRJP3 suppressed the production of not only IL-4 but also that of IL-2 and IFN-gamma by T cells concomitant with inhibition of proliferation. The MRJP3-mediated suppression of IL-4 production was also evident when lymph node cells from OVA/alum-immunized mice were stimulated with OVA plus antigen presenting cells. We next examined the purified suppressive factor on OVA/alum-induced allergic responses in mice. Interestingly, in spite of the antigenicity of MRJP3 itself as an extraneous foreign protein, intraperitoneal administration of MRJP3 inhibited serum anti-OVA IgE and IgG1 levels in immunized mice. In addition, heat-treated soluble MRJP3 treatment reduced its antigenicity while maintaining its inhibitory effects on antibody responses to OVA. These results indicate that MRJP3 can exhibit potent immunoregulatory effects in vitro and in vivo. Furthermore, considering the intriguing immunomodulatory effects of MRJP3, it may be of clinical significance to design MRJP3-derived antiallergic peptides by identifying the associated polypeptide regions.

PMID: 12899927 [PubMed - indexed for MEDLINE]

A royal jelly as a new potential immunomodulator in rats and mice.

• Sver L,

• Orsolic N,

• Tadic Z,

• Njari B,

• Valpotic I,

• Basic I.

Department of Biology, University of Zagreb, Croatia.

In order to study a possible immunomodulatory effect of the royal jelly (RJ) secreted by mandibular and hypopharingeal glands of the worker honeybee (Apis mellifera Linne.) we have used a well established rodent model. The CBA mice were given s.c. 0.1 ml of RJ, 7 days before, or immediately after, the immunization with sheep red blood cells (SRBC). The Y59 rats received i.m. 0.4 ml or i.v. 0.025 ml of RJ once or twice at 7 day intervals. Serum levels of total proteins and immunoglobulins in the rats that received RJ once or twice within a 2-week-period were significantly lower (P < or = 0.05) as compared with the nontreated animals. In mice which were immunized with 4 x 10(8) of SRBC 7 days after the application of RJ the number of plaque forming splenocytes was significantly higher (P < or = 0.05) than that in the controls. Both the weight of inguinal lymph node and the number of peripheral blood lymphocytes were increased (P < or = 0.05) in RJ-treated mice 3 or 5 days after the immunization, respectively. Neutrophils were decreased (P < or = 0.05) in the mice that were killed 5 or 10 days after the RJ treatment. Overall these results indicate that RJ exhibited immunomodulatory properties by stimulating antibody production and immunocompetent cell proliferation in mice or depressing humoral immune functions in rats. Both phenomena, though species-related in this model, could probably be reversed by changing the dose or the route of RJ application.

PMID: 8654043 [PubMed - indexed for MEDLINE]

Contamination of Royal Jelly

Chloramphenicol in royal jelly: analytical aspects and occurrence in Italian imports

Silvano Calvarese, Anna Francesca Forti, Giampiero Scortichini and Gianfranco Diletti

Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise "G. Caporale", Via Campo Boario, 64100 Teramo, Italy

(Received 18 May 2005 - Revised 31 January 2006 - Accepted 31 January 2006 - published online 17 October 2006)
 

Abstract - Chloramphenicol (CAP) residues were determined in 35 samples of royal jelly. Fourteen samples were collected by Veterinary Border Inspection officials in Milan and Turin and 21 were submitted by private importers to confirm the quality of their product. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used for the identification and determination of CAP, according to the isotope dilution approach for the analysis of royal jelly. The presence of chloramphenicol was detected in 29 out of 35 tested samples at concentrations ranging from 0.6 g/kg to 28 g/kg, with an average content of 6.1 g/kg.

As shows above, many samples of Royal Jelly had been discovered contaminated with Chloramphenicol.

Chloramphenicol (also called Chloromycetin) is a potent antibiotic that has limited uses.

Chloramphenicol has been declared carcinogenic, which makes it an unacceptable substance for use in production of food products where any residue may be found.

The problem of chloramphenicol contamination of bee products has been isolated to China. In sampling of honey from China during 2002, trace amounts of chloramphenicol had been found in most samples.

The reason chloramphenicol had appeared in Chinese bee products is that in 1997-98 there was a bacterial epidemic that affected bee hives which threatened the entire industry.

Beware of contaminated products. Use our Phytoflora Line of uncontaminated Royal Jelly products.