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Nucleo de Ciencia e Tecnologia, Area de Ciencias Biologicas e da Saude, Universidade do Oeste de Santa Catarina, Campus de Videira, SC, Brazil.
Propolis is a resinous hive product collected by honeybees from plants. The propolis produced in Southeastern of Brazil is known as green propolis because of its color. Modern herbalists recommend its use because it displays antibacterial, antifungal, antiviral, hepatoprotective, anti-inflammatory, immunomodulatory and anti-ulcer properties. The anti-ulcer activity of green propolis hydroalcoholic crude extract was evaluated by using models of acute gastric lesions induced by ethanol, indomethacin and stress in rats. Moreover, the effects of extract on gastric content volume, pH and total acidity, using pylorus ligated model were evaluated. Animals pretreated with propolis hydroalcoholic crude extract (50, 250 and 500mg/kg) showed a significant reduction in lesion index, total affected area and percentage of lesion in comparison with control group (p<0.05) in the ethanol-induced ulcer model. Green propolis extract, at a higher dose (500mg/kg), displayed a significant protection by reducing (p<0.05) the evaluated parameters in the gastric ulceration induced by indomethacin. In the stress-induced ulcer model it was observed a significant reduction (p<0.05) in those parameters in animals treated with green propolis extract (250 and 500mg/kg). Regarding the pylorus ligated model it was observed that green propolis extract (250 and 500mg/kg) displayed an anti-secretory activity, which lead to a reduction in the gastric juice volume, total acidity and pH. These findings indicate that Brazilian green propolis displays good anti-ulcer activity, corroborating the folk use of propolis preparations, and contributing for its pharmacological validation.
PMID: 17126509 [PubMed - in process]
Hepatoprotective and anti-Helicobacter pylori
activities of constituents from Brazilian propolis.
Banskota AH,
Tezuka Y,
Adnyana IK,
Ishii E,
Midorikawa K,
Matsushige K,
Kadota S.
Department of Natural Products Chemistry, Institute of Natural Medicine, Toyama
Medical and Pharmaceutical University, Japan.
Propolis is a resinous hive product collected by honeybees from various plant
sources. It is extensively used in food, beverage and in folk medicine for
treating various ailments and reported to have broad spectrum of biological
activities. The hepatoprotective activity of propolis and constituents from its
MeOH extract belonging to various classes were tested on D-galactosamine (D-GalN)/tumor
necrosis factor-alpha (TNF-alpha)-induced cell death in primary cultured mouse
hepatocytes. The result indicated that hepatoprotective activity of alcoholic
extract of tropical Brazilian propolis is mainly due to phenolic compounds
including flavonoids. All the four isolated flavonoids possessed stronger
inhibitory activity (IC50, < 25 microM) than silibinin (IC50, 39.6 microM) on
TNF-alpha-induced cell death. The labdane-type diterpenes isolated from the MeOH
extract also exhibited significant hepatoprotective activity in the same
experimental model. Moreover, the labdane-type diterpenes and some of the
prenylated phenolic compounds possessed antibacterial activity against
Helicobacter pylori.
PMID: 11292234 [PubMed - indexed for MEDLINE]
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