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It
is produced at 60 Brix Grade.
We recommend it to people who are not able, or don't like, to use alcoholic
products.
This product is Wax Free, which means, no residue
when diluted in water.
Propolis is a balm-resinous
substance that has several types of consistences and colorations, varying from brown to
dark green. Bees collect it from several parts of the plants as sprouts, floral
buttons and resinous exudates, being transported inside of the beehive and
modified by the bees through its own enzymes. This substance is used by the bees
in the entrance of the beehives in order to close openings, to avoid the
penetration of cold wind and natural enemies (fungus and
bacteria). Propolis is also used as construction material inside the beehive,
welding honeycombs, frames and polishing the interior of the alveoli for the
queen to do the posture.
The chemical composition of propolis depends on the botanical ecology of each
area and by the bee race, but generally, it is compose 50% of resin and balm,
30% of wax, 10% of essential and aromatic oils, 5% of pollen and 5% of several
other substances. Until now, there are already more than 200 chemical
compounds identified in the propolis, like flavonoids, aromatic acids,
terpenoids, aldehydes, alcohols, aliphatic acid and esters, amino acids,
steroids, sugar, etc.
Recent
studies on tropical samples, especially Brazilian, lead to the discovery of new
antibacterial compounds. A number of them are phenolics and their
derivatives, although completely different from those found in European
propolis. The most important ones are carbon-prenylated derivatives of p-coumaric
acid, the 3,5-diprenyl-p-coumaric acid being one of the major antibacterial
compounds in Brazilian propolis (Aga et al., 1994).
In countries of temperate
climate from Europe and North America, the vegetables producing propolis are
very few. The poplar, Populus L., of the family of Salicaceae is the main
source. This vegetal species still can be found in Asia and North Africa.
However, it is not regular in the tropics. There are several species in Brazil
from which we can extract this resin. However, few species were identified so far, but roast-fish, aroeira, rosemary and eucalyptus are some examples of
vegetables that produce propolis.
Intensive researches performed in
the Brazilian Green Propolis reveal that these compounds are the agents for its
several physiologic actions: anti-microbe (it works as a natural antibiotic),
anti-inflammatory, healing, anesthetic, antioxidant (it combats free radicals),
anti-fungal, anti protozoa, antiviral and also anticancer.
Special
attention has been directed toward the anti-tumor effects of propolis.
Caffeic acid phenethyl ester (CAPE) is the anti-tumor substances from propolis
that has received the most attention. Its anti-tumor properties were discovered
in a bioassay-guided chemical study of propolis by the research group of Koji
Nakanishi (Grundberger et al., 1988) and examined thoroughly. CAPE was found to
inhibit human breast carcinoma and melanoma cell lines in culture. Human tumor
cells displayed a significantly greater sensitivity to the action of CAPE than
the analogous normal lines of non-tumorous cells in that the CAPE was more toxic
to the tumor cells than to the normal ones.
Similar results were obtained
using other propolis constituents with similar structures: methyl caffeate and
phenethyl ester of dimethylcaffeic acid (Rao et al., 1992). Brazilian propolis
delivered structurally different anti-tumor agents: carbon-prenylated
derivatives of p-coumaric acids, e.g. 3,5-diprenyl-p-coumaric acid and similar
molecules showed cytotoxic activity in vitro against human tumor cell
lines, as well as in vivo in mice transplanted with human tumor cells (Kimoto et
al., 1998). Another group of anti-tumor propolis constituents was isolated from
Brazilian samples, too: clerodane diterpenic acids, active against human
hepatocelular carcinoma (Matsuno et al., 1997). At present this field is being
studied extensively by several research group in Japan.
Uniflora Propolis Extracts are made
with 100% Brazilian Green Propolis highly concentrated (considered one of the best
in the world), obtained from controlled raw propolis, collected in areas
free of contamination, using equipment developed to maximize the extraction
process.
Uniflora has a staff with full knowledge and equipments highly necessary to
accomplish the manipulation and the quality control of our propolis extracts.
In this way, we can guarantee that the high properties of the propolis are not being
harmed or wasted.
Anti-influenza virus effect of some propolis
constituents and their analogues (esters of substituted cinnamic acids).
Serkedjieva J,
Manolova N,
Bankova V.
Institute of Microbiology, Bulgarian Academy of Sciences, Sofia.
The antiviral activity of six synthetic substances, esters of substituted
cinnamic acids, identical with or analogous to some of the constituents of the
Et2O fraction of propolis was studied in vitro. One of them, isopentyl ferulate,
inhibited significantly the infectious activity of influenza virus A/Hong Kong
(H3N2) in vitro and the production of hemagglutinins in egg. By the use of
diverse experimental patterns, it was found that the maximal inhibition of viral
reproduction was observed when test substances were present in the medium during
the whole infectious process.
PMID: 1593279 [PubMed - indexed for MEDLINE]
Published in Cancer Detection and Prevention
1998; 22(6):506-515.
Apoptosis and Suppression of Tumor
Growth by Artepillin C Extracted From Brazilian Propolis
Tetsuo Kimoto, M.D., Ph.D.,a Shigeyuki
Arai, D.V.M., Ph.D.,a Michihiro Kohguchi, B.S., a Miho Aga, B.Pharm.,a Yutaka
Nomura, B.S., a Mark J. Micallef, Ph.D.,a Masashi Kurimoto, M.S.,a and Keiichiro
Mito, Ph.D.b
ABSTRACT: Artepillin C
was extracted from Brazilian propolis. Artepillin C
(3,5-diprenyl-4-hydroxycinnamic acid) has a molecular weight of 300.40 and
possesses antibacterial activity. When artepillin C was applied to human and
murine malignant tumor cells in vitro and in vivo, artepillin C
exhibited a cytotoxic effect and the growth of tumor cells was clearly
inhibited. The artepillin C was found to cause significant damage to solid tumor
and leukemic cells by the MTT assay, DNA synthesis assay, and morphological
observation in vitro. When xenografts of human tumor cells were
transplanted into nude mice, the cytotoxic effects of artepillin C were most
noticeable in carcinoma and malignant melanoma. Apoptosis, abortive mitosis, and
massive necrosis combined were identified by histological observation after
intratumor injection of 500 μg of artepillin C three times a week. In addition
to suppression of tumor growth, there was an increase in the ratio of CD4/CD8 T
cells, and in the total number of helper T cells. These findings indicate that
artepillin C activates the immune system, and possesses direct antitumor
activity.